No structural brain alterations in new daily persistent headache : a cross sectional VBM/SBM study

GND
1063285992
ORCID
0000-0003-1727-9362
Affiliation
Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany
Nägel, Steffen;
GND
1220438634
Affiliation
Department of Neurology, Westgerman Headache Center, University of Duisburg-Essen, University Hospital Essen, Essen, Germany
Zeller, Julia;
Affiliation
Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Hougaard, Anders;
GND
1127613006
Affiliation
Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany
Weise, Christopher Michael;
GND
1097389189
LSF
55474
Affiliation
Department of Diagnostic and Interventional Radiology and Neuroradiology, University of Duisburg-Essen, University Hospital Essen, Essen, Germany
Zülow, Stefan;
GND
123343909
ORCID
0000-0002-1650-8875
LSF
58465
Affiliation
Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany
Kleinschnitz, Christoph;
GND
132019345
Affiliation
Department of Neurology, Westgerman Headache Center, University of Duisburg-Essen, University Hospital Essen, Essen, Germany
Obermann, Mark;
GND
1213999669
Affiliation
Department of Neurology, Westgerman Headache Center, University of Duisburg-Essen, University Hospital Essen, Essen, Germany
Solbach, Kasja Friederike;
GND
132478552
LSF
55495
Affiliation
Department of Neurology, Westgerman Headache Center, University of Duisburg-Essen, University Hospital Essen, Essen, Germany
Holle, Dagny

Objective: To identify grey matter alterations in patients suffering new daily persistent headache to enrich the pathophysiological concept of this rare headache disorder characterised by a distinct, clearly remembered onset and its instant chronification.

Method: Magnetic resonance-based voxel-based and surface-based morphometry was used to investigate 23 patients suffering from new daily persistent headache and 23 age- and gender-matched healthy controls with 1.5 Tesla MRI. Independent statistical analysis was performed at three sites using statistical parametric mapping, as well as FSL(FMRIB Software Library)-based approaches.

Results: No grey matter changes were detected using this sophisticated and cross-checked method.

Conclusion: The absence of structural brain changes in patients with new daily persistent headache contribute to the recent discussion regarding structural alterations in primary headache disorders in general and does not provide evidence for grey matter changes being associated with the pathophysiology of new daily persistent headache. Future research will have to determine the underlying pathophysiological mechanisms of this disorder.

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© International Headache Society 2021

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