Male-pattern baldness and incident coronary heart disease and risk factors in the Heinz Nixdorf Recall Study

GND
133930653
ORCID
0000-0002-6181-7044
LSF
50554
Affiliation
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
Pechlivanis, Sonali;
ORCID
0000-0003-1057-465X
Affiliation
Institute of Human Genetics, University of Bonn, Bonn, Germany.
Heilmann-Heimbach, Stefanie;
GND
108550877
ORCID
0000-0001-9884-0785
LSF
14806
Affiliation
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
Erbel, Raimund;
GND
1020106387
ORCID
0000-0003-2336-7991
LSF
55122
Affiliation
Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, Essen, Germany.
Mahabadi, Amir A.;
GND
1204444501
Affiliation
Institute of Human Genetics, University of Bonn, Bonn, Germany.
Hochfeld, Lara M.;
GND
171154290
LSF
10462
Affiliation
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
Jöckel, Karl-Heinz;
GND
1069221139
Affiliation
Institute of Human Genetics, University of Bonn, Bonn, Germany.
Nöthen, Markus Maria;
GND
141370688
ORCID
0000-0002-0072-5410
LSF
16190
Affiliation
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
Moebus, Susanne

Male-pattern baldness (MPB) is characterized by a progressive hair loss from the frontal and vertex scalp that affects about 80% of men at the age of 80 years. Epidemiological studies show positive associations between MPB and coronary heart disease (CHD) and CHD related risk factors such as blood pressure (BP), diabetes mellitus (DM) or elevated blood lipid levels. The results however vary with regard to the pattern of hair loss (i.e. moderate, severe, frontal or vertex). Further, no study has investigated for a shared genetic determinant between MPB and CHD as well as CHD related risk factors. Using the longitudinal data from the population-based Heinz Nixdorf Recall study we aimed to systematically investigate the association between MPB and incident CHD and CHD risk factors on (i) an epidemiological (N = 1,673 males) and (ii) a genetic (N = 1,357 males) level. The prevalence of any baldness in our study population was 88% (mean age ± SD: 64±7.5 years). Compared to men with 'no baldness', in men with any kind of baldness a slightly increased risk for CHD (Hazard ratio [95% confidence interval (95%CI)] = 1.2 [0.8; 1.9]), a slightly higher extend of coronary artery calcification (CAC) (Beta [95%CI] = 0.2 [-0.1; 0.6]), a moderately increased risk for DM (prevalence ratio [95%CI] = 1.4 [0.9; 2.0]) and higher body mass index (BMI) (Beta [95%CI] = 0.6 [0.00003; 1.2]) seem to be indicated in the adjusted model. In contrast, the MPB genetic risk score did not show any association with CHD or CHD risk factors. Taken together, the results of our study suggest a weak association between MPB and a few CHD risk factors (CAC, DM and BMI) but do not point to MPB as a strong surrogate measure for CHD and CHD risk factors in general.

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Pechlivanis, S., Heilmann-Heimbach, S., Erbel, R., Mahabadi, A.A., Hochfeld, L.M., Jöckel, K.-H., Nöthen, M.M., Moebus, S., 2019. Male-pattern baldness and incident coronary heart disease and risk factors in the Heinz Nixdorf Recall Study. https://doi.org/10.1371/journal.pone.0225521
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