000K  utf8
1100  2019$c2019-11-19
1500  eng
2050  urn:nbn:de:hbz:464-20200528-141518-7
2051  10.1371/journal.pone.0225521
3000  Pechlivanis, Sonali
3010  Erbel, Raimund
3010  Heilmann-Heimbach, Stefanie
3010  Hochfeld, Lara M.
3010  Jöckel, Karl-Heinz
3010  Mahabadi, Amir A.
3010  Moebus, Susanne
3010  Nöthen, Markus Maria
4000  Male-pattern baldness and incident coronary heart disease and risk factors in the Heinz Nixdorf Recall Study  [Pechlivanis, Sonali]
4209  Male-pattern baldness (MPB) is characterized by a progressive hair loss from the frontal and vertex scalp that affects about 80% of men at the age of 80 years. Epidemiological studies show positive associations between MPB and coronary heart disease (CHD) and CHD related risk factors such as blood pressure (BP), diabetes mellitus (DM) or elevated blood lipid levels. The results however vary with regard to the pattern of hair loss (i.e. moderate, severe, frontal or vertex). Further, no study has investigated for a shared genetic determinant between MPB and CHD as well as CHD related risk factors. Using the longitudinal data from the population-based Heinz Nixdorf Recall study we aimed to systematically investigate the association between MPB and incident CHD and CHD risk factors on (i) an epidemiological (N = 1,673 males) and (ii) a genetic (N = 1,357 males) level. The prevalence of any baldness in our study population was 88% (mean age ± SD: 64±7.5 years). Compared to men with 'no baldness', in men with any kind of baldness a slightly increased risk for CHD (Hazard ratio [95% confidence interval (95%CI)] = 1.2 [0.8; 1.9]), a slightly higher extend of coronary artery calcification (CAC) (Beta [95%CI] = 0.2 [-0.1; 0.6]), a moderately increased risk for DM (prevalence ratio [95%CI] = 1.4 [0.9; 2.0]) and higher body mass index (BMI) (Beta [95%CI] = 0.6 [0.00003; 1.2]) seem to be indicated in the adjusted model. In contrast, the MPB genetic risk score did not show any association with CHD or CHD risk factors. Taken together, the results of our study suggest a weak association between MPB and a few CHD risk factors (CAC, DM and BMI) but do not point to MPB as a strong surrogate measure for CHD and CHD risk factors in general.
4950  https://doi.org/10.1371/journal.pone.0225521$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:hbz:464-20200528-141518-7$xR$3Volltext$534
4961  https://duepublico2.uni-due.de/receive/duepublico_mods_00071344
5051  610