Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects

Milos, Gabriella; Antel, Jochen; Kaufmann, Lisa-Katrin; Barth, Nikolaus; Koller, Antonia; Tan, Susanne; Wiesing, Urban; Hinney, Anke; Libuda, Lars; Wabitsch, Martin; von Känel, Roland; Hebebrand, Johannes

doi:10.1038/s41398-020-00977-1

Artikel / Aufsatz Do., 27. Aug.. 2020 CC BY 4.0

Veröffentlicht

Short-term metreleptin treatment of patients with anorexia nervosa : rapid on-set of beneficial cognitive, emotional, and behavioral effects

Milos, Gabriella ; Antel, Jochen ; Kaufmann, Lisa-Katrin ; Barth, Nikolaus ; Koller, Antonia ; Tan, Susanne ; Wiesing, Urban ; Hinney, Anke ; Libuda, Lars ; Wabitsch, Martin ; von Känel, Roland ; Hebebrand, Johannes

To examine the hypothesis that normalization of low circulating leptin levels in patients with anorexia nervosa ameliorates hyperactivity, three seriously ill females with hyperactivity were treated off-label with metreleptin (recombinant human leptin) for up to 14 days. Drive for activity, repetitive thoughts of food, inner restlessness, and weight phobia decreased in two patients. Surprisingly, depression improved rapidly in all patients. No serious adverse events occurred. Due to obvious limitations of uncontrolled case series, placebo-controlled clinical trials are mandatory to confirm the observed rapid onset of beneficial effects. Our findings suggest an important role of hypoleptinemia in the mental and behavioral phenotype of anorexia nervosa.

Vorschau

Einordnung

Datum der Veröffentlichung:

27.08.2020

URN:

urn:nbn:de:hbz:465-20240814-102137-6

DOI:

10.1038/s41398-020-00977-1

Sprache:

Englisch

Ressourcentyp:

Text

Kollektion:

E-Publikationen

Sachgruppen der Deutschen Nationalbibliographie:

610 Medizin, Gesundheit

Einrichtung:

Medizinische Fakultät, Universitätsklinikum Essen, LVR-Klinikum Essen, Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters

Einrichtung:

Medizinische Fakultät, Universitätsklinikum Essen, Klinik für Endokrinologie, Diabetologie und Stoffwechsel

Einrichtung:

Forschungszentren, Zentrum für Medizinische Biotechnologie (ZMB)

Förderung:

The publication of this article was supported by the Publication Fund of the University of Duisburg-Essen.

Financial support was provided by Christina Barz Stiftung and intramural research funds from the University Hospitals Essen and Zurich. These case studies would not have been possible without (long-term) funding of J.H., A.H., and L.L. for leptin-related research by both German Ministry of Education and Research (BMBF) and Deutsche Forschungsgemeinschaft (e.g., HE 1446/12-1 and LI 2711/2-1).

Open access funding provided by Projekt DEAL.

Informationen zur Erstveröffentlichung:

Milos, G., Antel, J., Kaufmann, LK. et al. Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects. Transl Psychiatry 10, 303 (2020). https://doi.org/10.1038/s41398-020-00977-1

Published 27 August 2020

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