Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes

Hebebrand, Johannes; Antel, Jochen; von Piechowski, Linda; Kiewert, Cordula; Stüve, Burkhard; Gradl-Dietsch, Gertraud

doi:10.3389/fpsyt.2023.1267495

Artikel / Aufsatz Do., 09. Nov.. 2023 CC BY 4.0

Veröffentlicht

Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes

Hebebrand, Johannes ; Antel, Jochen ; von Piechowski, Linda; Kiewert, Cordula ; Stüve, Burkhard; Gradl-Dietsch, Gertraud

A comorbidity of anorexia nervosa (AN) and myalgic encephalomyelitis (ME/CSF) is uncommon. A 17 years-old male adolescent with possible onset of ME/CFS after an Epstein Barr Virus infection (EBV) and later onset of AN during a second period of weight loss was twice treated off-label with metreleptin for 15 and 11 days, respectively. As in previous cases, eating disorder specific cognitions and mood improved. Interestingly, fatigue and post-exertional muscle pain (P-EMP) improved, too. We discuss potential mechanisms. Treatment with metreleptin may prove beneficial in AN and in ME/CSF associated with substantial weight loss.

Vorschau

Einordnung

Datum der Veröffentlichung:

09.11.2023

URN:

urn:nbn:de:hbz:465-20240612-113324-6

DOI:

10.3389/fpsyt.2023.1267495

Sprache:

Englisch

Ressourcentyp:

Text

Schlagwörter:

leptin; muscle; exhaustion; fatigue; depression; sleep quality

Kollektion:

E-Publikationen

Sachgruppen der Deutschen Nationalbibliographie:

610 Medizin, Gesundheit

Einrichtung:

Medizinische Fakultät, Universitätsklinikum Essen, LVR-Klinikum Essen, Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters

Einrichtung:

Medizinische Fakultät, Universitätsklinikum Essen, Zentrum für Kinder- und Jugendmedizin, Klinik für Kinderheilkunde II

Einrichtung:

Medizinische Fakultät, Universitätsklinikum Essen, Center for Translational Neuro- and Behavioral Science (C-TNBS)

Förderung:

The publication of this article was supported by the Publication Fund of the University of Duisburg-Essen.

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This case study was supported financially by the University of Duisburg-Essen.

Informationen zur Erstveröffentlichung:

Hebebrand J, Antel J, von Piechowski L, Kiewert C, Stüve B and Gradl-Dietsch G (2023) Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes. Front. Psychiatry. 14:1267495. doi:10.3389/fpsyt.2023.1267495

Published: 09 November 2023

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