The influence of ABO blood group on mortality in major trauma

GND
14198788X
LSF
12880
Affiliation
Department of General and Trauma Surgery, BG University Hospital Bergmannsheil, Bochum.
Hamsen, Uwe;
Affiliation
Department of General and Trauma Surgery, BG Klinikum Duisburg.
Nohl, André;
Affiliation
Department of Anesthesia, Pain- and Palliative Care, BG University Hospital Bergmannsheil, Bochum.
Baumann, Andreas;
Affiliation
Institut für Forschung in der Operativen Medizin (IFOM), Universität Witten/Herdecke, Köln.
Lefering, Rolf;
Affiliation
Alfried Krupp Krankenhaus Rüttenscheid, Essen.
Boutakmant, Laila;
GND
1114423130
LSF
14423
Affiliation
Department of General and Trauma Surgery, BG University Hospital Bergmannsheil, Bochum.
Waydhas, Christian;
GND
135917603
LSF
58300
Affiliation
Department of Trauma Surgery, University Hospital Essen.
Dudda, Marcel;
Affiliation
Department of General and Trauma Surgery, BG University Hospital Bergmannsheil, Bochum.
Schildhauer, Thomas Armin;
GND
121756394
Affiliation
Department of Orthopaedics and Trauma Surgery, University Hospital Essen, Germany.
Jäger, Marcus;
GND
135601428
LSF
57001
Affiliation
Department of Orthopaedics and Trauma Surgery, University Hospital Essen, Germany.
Wegner, Alexander

ABO blood group has a profound influence on hemostasis as it is a major determinant of plasma levels of von Willebrand Factor. In vitro studies suggest that blood group O is a risk factor for increased severe bleeding while blood group non-O is a risk factor for thromboembolic events. Yet, the impact of ABO blood group outcome after multiple trauma is unknown. Retrospective multicenter case-control study from three level-1 trauma centers in Germany from 2012-2015. Inclusion criteria were severe trauma with an Injury severity score ≥9 and admission to an intensive care unit. 1281 patients (69.5% male) were included. Mean Injury Severity Score (ISS) was 21.1±12.4; mean age was 50.2±22.4 years. Distribution of blood groups was: O: 37.4%; A: 44%, B: 12.7 and AB: 5.8%. Hospital mortality depending on blood group was 9.7 (A), 10.4 (B), 6.8 (AB) and 12.7 (O) %. Multivariant logistic regression for mortality revealed an Odds ratio of 0.79 (A), 0.60 (B) and 0.54 (AB) without statistical significance (P=0.35 (A), 0.17 (B), 0.33 (AB)). Thromboembolic events (blood group O vs. others) occurred in 2.8 (O) vs. 3.3 (others) %, P=0.619. In this retrospective study on 1281 multiple injured patients, no relevant influence of ABO blood group on hemorrhage, thromboembolic events and mortality could be found.

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Hamsen, U., Nohl, A., Baumann, A., Lefering, R., Boutakmant, L., Waydhas, C., Dudda, M., Schildhauer, T.A., Jäger, M., Wegner, A., 2019. The influence of ABO blood group on mortality in major trauma. https://doi.org/10.4081/or.2019.8214
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