Structural Analysis of the 42 kDa Parvulin of Trypanosoma brucei

Rehic, Edisa; Hönig, Dana LSF; Kamba, Bianca E. LSF; Göhring, Anna LSF; Hofmann, Eckhard; Gasper, Raphael; Matena, Anja; Bayer, Peter LSF

Trypanosoma brucei is a unicellular eukaryotic parasite, which causes the African sleeping sickness in humans. The recently discovered trypanosomal protein Parvulin 42 (TbPar42) plays a key role in parasite cell proliferation. Homologues of this two-domain protein are exclusively found in protozoa species. TbPar42 exhibits an N-terminal forkhead associated (FHA)-domain and a peptidyl-prolyl-cis/trans-isomerase (PPIase) domain, both connected by a linker. Using NMR and X-ray analysis as well as activity assays, we report on the structures of the single domains of TbPar42, discuss their intra-molecular interplay, and give some initial hints as to potential cellular functions of the protein.

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Rehic, Edisa / Hönig, Dana / Kamba, Bianca E. / et al: Structural Analysis of the 42 kDa Parvulin of Trypanosoma brucei. 2019.

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