We discuss how Dirichlet boundary conditions can be directly imposed for the Moulinec–Suquet discretization on the boundary of rectangular domains in iterative schemes based on the fast Fourier transform (FFT) and computational homogenization problems in mechanics. Classically, computational homogenization methods based on the fast Fourier transform work with periodic boundary conditions. There are applications, however, when Dirichlet (or Neumann) boundary conditions are required. For thermal homogenization problems, it is straightforward to impose such boundary conditions by using discrete sine (and cosine) transforms instead of the FFT. This approach, however, is not readily extended to mechanical problems due to the appearance of mixed derivatives in the Lamé operator of elasticity. Thus, Dirichlet boundary conditions are typically imposed either by using Lagrange multipliers or a “buffer zone” with a high stiffness. Both strategies lead to formulations which do not share the computational advantages of the original FFT-based schemes. The work at hand introduces a technique for imposing Dirichlet boundary conditions directly without the need for indefinite systems. We use a formulation on the deformation gradient—also at small strains—and employ the Green’s operator associated to the vector Laplacian. Then, we develop the Moulinec–Suquet discretization for Dirichlet boundary conditions—requiring carefully selected weights at boundary points—and discuss the seamless integration into existing FFT-based computational homogenization codes based on dedicated discrete sine/cosine transforms. The article culminates with a series of well-chosen numerical examples demonstrating the capabilities of the introduced technology.