The rail vehicle industry wants to produce vehicles with higher speeds, to maintain and increase its market share. However, when the speed of the vehicle increases, it may have an undesirable effect on ride comfort, in terms of ride dynamics. Recent developments towards lighter and faster vehicles make the problem of ride comfort at higher speeds increasingly important. Focusing on the behavior of flexible rather than rigid body behavior should not be neglected when designing long and light car bodies. There are several approaches to incorporate body flexibility in multibody simulations and they have some superiorities and weaknesses. In this study, an efficient and accurate vertical dynamic model for the ride comfort analysis is developed and implemented in a commercial object-oriented modeling (OOM) software DYMOLA (2015 FD01) which uses the open-source code MODELICA. This model includes car body flexibility with the assembling of a rigid body approach. The developed model is compared to a three-dimensional vehicle model in the commercial VAMPIRE software (Pro V5.50) at different velocities. For the vertical ride comfort analysis, the ISO 2631-1 standard was used for both the developed model and the three-dimensional model. The results are presented as acceleration history and a^wrms—weighted r.m.s (root mean square) of accelerations—as required by the standard. The developed model has shown its feasibility in terms of its efficiency and accuracy for the vertical ride comfort analysis. The accuracy of the model is evidenced by the fact that the car body vibration level at high speeds shows minor differences compared to the results of the VAMPIRE, which is a validated commercial software in the area of rail vehicle dynamics. The approach involving the assembly of rigid bodies is applied for the first time for high-speed trains in dynamical modelling, with flexible car bodies for ride comfort analysis. Furthermore, it can be used for parametrical studies focusing on ride comfort, thereby offering a quite beneficial framework for addressing the challenges of ride comfort analysis in high-speed rail vehicles. Improvements for and analyses of other aspects are also possible, since the optimization and other useful libraries are readily available in DYMOLA / MODELICA.