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Antibody responses elicited by mRNA vaccination in firefighters persist six months and correlate inversely with age and directly with BMI

Knowledge regarding the sustainability of immune responses after COVID-19 vaccination is important, e.g., to decide whom and when to booster. Thus, we analyzed antibody titers in firefighters six months after vaccination with the mRNA-based vaccine Comirnaty. SARS-CoV-2 spike-binding antibodies (bAb) were quantified and compared to peak responses determined in healthcare workers (HCW). For the firefighters, neutralizing antibodies (nAb) were also analyzed. Six months after the second vaccine dose, all analyzed firefighters had detectable bAb, and 91% exhibited nAb titers above 1:16. However, actual titers six months after vaccination were over 12-fold lower than in the HCW control group four weeks after vaccination. bAb and nAb responses showed a significant correlation, and age correlated inversely with antibody responses. Unexpectedly, participants with a body mass index over 25 had higher neutralization titers after six months. All participants with very low neutralization titers were offered booster vaccination. The booster vaccination improved the extent and sustainability of antibody responses.

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Einordnung

Datum der Veröffentlichung:
30.12.2022
URN:
urn:nbn:de:hbz:465-20230626-144036-7
DOI:
10.1016/j.heliyon.2022.e12746
Sprache:
Englisch
Ressourcentyp:
Text
Schlagwörter:
COVID-19; SARS-CoV-2; Firefighters; Body mass index (BMI); Vaccination; mRNA vaccine; Antibodies; Neutralization
Kollektion:
E-Publikationen
Sachgruppen der Deutschen Nationalbibliographie:
610 Medizin, Gesundheit
Einrichtung:
Medizinische Fakultät, Universitätsklinikum Essen, Institut für Virologie
Einrichtung:
Medizinische Fakultät, Universitätsklinikum Essen, Zentrum für Orthopädie und Unfallchirurgie, Klinik für Unfall-, Hand- und Wiederherstellungschirurgie
Einrichtung:
Medizinische Fakultät, Universitätsklinikum Essen, Institut für Pharmakogenetik
Förderung:

The publication of this article was supported by the Publication Fund of the University of Duisburg-Essen.

Informationen zur Erstveröffentlichung:

Holtkamp, C., Schöler, L., Anastasiou, O. E., Brune, B., Fessmann, K., Elsner, C., Möhlendick, B., Ciuciulkaite, I., Dudda, M., Trilling, M., Dittmer, U., Spors, J., & Le-Trilling, V. T. K. (2023). Antibody responses elicited by mRNA vaccination in firefighters persist six months and correlate inversely with age and directly with BMI. Heliyon 9:e12746. https://doi.org/10.1016/j.heliyon.2022.e12746

Published: December 30, 2022

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