Visual snow syndrome is probably not mediated by CGRP : A case series

Affiliation
Department of Neurology, Krankenhaus Lindenbrunn, Coppenbrügge, Germany
Evers, Stefan;
GND
132478552
LSF
55495
Affiliation
Department of Neurology, University of Essen, Germany
Holle-Lee, Dagny;
ORCID
0000-0003-4668-6098
Affiliation
Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
Schankin, Christoph J.;
Affiliation
Department of Neurology, Charité Universitätsmedizin Berlin, Germany
Kull, Pia;
ORCID
0000-0001-9758-1494
Affiliation
Department of Neurology, Charité Universitätsmedizin Berlin, Germany
Raffaelli, Bianca

Background: Visual snow syndrome is a phenomenon for which no effective treatment is known. It is highly comorbid with migraine, therefore we performed a retrospective chart review of patients with visual snow syndrome treated with a monoclonal antibody against calcitonin gene related peptide or its receptor.

Findings: We enrolled 15 patients with visual snow syndrome who received at least once a monoclonal antibody against calcitonin gene related peptide or its receptor. None of the patients reported relief of visual snow syndrome whereas those patients with comorbid migraine reported a very good efficacy of the antibody against the migraine headache but not against the migraine aura.

Conclusion: The data suggest that visual snow syndrome is not mediated by calcitonin gene related peptide in a relevant way and that the calcitonin gene related peptide receptor is not involved in the network underlying the visual snow syndrome.

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© International Headache Society 2022

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