The impact of age and electrode position on amplitude-integrated EEGs in children from 1 month to 17 years of age

Greve, Sandra; Löffelhardt, Verena Tamara;
GND
1211607135
Affiliation
C-TNBS, Centre for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen ,Essen ,Germany
Della Marina, Adela;
GND
129094153
ORCID
0000-0002-7765-8893
LSF
50511
Affiliation
C-TNBS, Centre for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen ,Essen ,Germany
Felderhoff-Müser, Ursula;
GND
1033312193
LSF
51013
Dohna-Schwake, Christian;
GND
1166334090
ORCID
0000-0003-3809-1887
Affiliation
C-TNBS, Centre for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen ,Essen ,Germany
Bruns, Nora

Aim: Amplitude-integrated electroencephalography (aEEG) is used to monitor electrocortical activity in critically ill children but age-specific reference values are lacking. We aimed to assess the impact of age and electrode position on aEEG amplitudes and derive normal values for pediatric aEEGs from neurologically healthy children.

Methods: Normal EEGs from awake children aged 1 month to 17 years (213 female, 237 male) without neurological disease or neuroactive medication were retrospectively converted into aEEGs. Two observers manually measured the upper and lower amplitude borders of the C3 – P3, C4 – P4, C3 – C4, P3 – P4, and Fp1 – Fp2 channels of the 10–20 system. Percentiles (10th, 25th, 50th, 75th, 90th) were calculated for each age group (<1 year, 1 year, 2–5 years, 6–9 years, 10–13 years, 14–17 years).

Results: Amplitude heights and curves differed between channels without sex-specific differences. During the first 2 years of life, upper and lower amplitudes of all but the Fp1–Fp2 channel increased and then declined until 17 years. The decline of the upper Fp1–Fp2 amplitude began at 4 years, while the lower amplitude declined from the 1st year of life.

Conclusions: aEEG interpretation must account for age and electrode positions but not for sex in infants and children.

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