The use of virtual sensors in vehicles represents a cost-effective alternative to the installation of physical hardware. In addition to physical models resulting from theoretical modeling, artificial intelligence and machine learning approaches are increasingly used, which incorporate experimental modeling. Due to the resulting black-box characteristics, virtual sensors based on artificial intelligence are not fully reliable, which can have fatal consequences in safety-critical applications. Therefore, a hybrid method is presented that safeguards the reliability of artificial intelligence-based estimations. The application example is the state estimation of the vehicle roll angle. The state estimation is coupled with a central predictive vehicle dynamics control. The implementation and validation is performed by a co-simulation between IPG CarMaker and MATLAB/Simulink. By using the hybrid method, unreliable estimations by the artificial intelligence-based model resulting from erroneous input signals are detected and handled. Thus, a valid and reliable state estimate is available throughout.