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Prevalence of COVID-19 Associated Mucormycosis in a German Tertiary Care Hospital

Due to Coronavirus disease (COVID-19) a new group of patients at risk emerged with COVID-19-associated mucormycosis (CAM). Systematic studies, evaluating the prevalence of CAM are missing. To assess CAM prevalence in a tertiary care hospital in Germany, we applied direct microscopy, fungal culture and quantitative realtime in-house PCR targeting Mucorales-specific fragments of 18S and 28S rRNA on respiratory specimens of 100 critically ill COVID-19 patients. Overall, one Mucorales-PCR positive bronchoalevolar lavage was found whereas direct microscopy and fungal culture were negative in all cases. We conclude that a routine screening for CAM in Germany is not indicated.

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Date Issued:
17.03.2022
URN:
urn:nbn:de:hbz:465-20220817-161043-5
DOI:
10.3390/jof8030307
Language:
English
Type of Resource:
Text
Keywords:
SARS-CoV-2; COVID-19; fungal infection; mucormycosis; Mucorales qPCR
Collection:
E-Publications
Subject categories of the Deutsche Nationalbibliografie:
610 Medical sciences Medicine
Hosting institution:
Faculty of Medicine, Essen University Hospital, Institute of Medical Microbiology
Hosting institution:
Faculty of Medicine, Essen University Hospital, Clinic for Anesthesiology and Intensive Care
Hosting institution:
Faculty of Medicine, Essen University Hospital, Clinic for Bone Marrow Transplants
Info on primary publication:

Scharmann U, Herbstreit F, Steckel NK, Dedy J, Buer J, Rath P-M, Verhasselt HL. (2022). Prevalence of COVID-19 Associated Mucormycosis in a German Tertiary Care Hospital. Journal of Fungi, 8(3):307. https://doi.org/10.3390/jof8030307

Published: 17 March 2022

version identification:
Version of Record / Verlagsversion
funding:

The publication of this article was supported by the Publication Fund of the University of Duisburg-Essen.

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