Entwicklung einer einheitlichen Strategie zur Synthese aller Aldohexosen auf Basis von Matteson-Homologisierungen

The aim of this thesis was the development of a strategy towards a unified synthesis of aldohexoses that allow addressing each stereocenter as well as each protecting group. The strategy included the synthesis of sugar alcohols and their conversion into aldohexoses by ring closure over both ends. This is advantageous for isotopic labelling due to late‑stage functionalisation. The synthesis by assembly of C1-building blocks makes it possible to perform isotopic labelling on specific positions in the molecule. Additionally, this method allows for addressing the hydroxyl groups individually as well as each stereocenter.


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