Background: In the assessment of diseases causing skeletal lesions such as multiple myeloma (MM), whole-body low-dose computed tomography (WBLDCT) is a sensitive diagnostic imaging modality, which has the potential to replace the conventional radiographic survey.

Purpose: To optimize radiation protection and examine radiation exposure, and effective and organ doses of WBLDCT using different modern dual-source CT (DSCT) devices, and to establish local diagnostic reference levels (DRL).

Material and Methods: In this retrospective study, 281 WBLDCT scans of 232 patients performed between January 2017 and April 2020 either on a second- (A) or third-generation (B) DSCT device could be included. Radiation exposure indices and organ and effective doses were calculated using a commercially available automated dose-tracking software based on Monte-Carlo simulation techniques.

Results: The radiation exposure indices and effective doses were distributed as follows (median, interquartile range): (A) second-generation DSCT: volume-weighted CT dose index (CTDI vol ) 1.78 mGy (1.47–2.17 mGy); dose length product (DLP) 282.8 mGy·cm (224.6–319.4 mGy·cm), effective dose (ED) 1.87 mSv (1.61–2.17 mSv) and (B) third-generation DSCT: CTDI vol 0.56 mGy (0.47–0.67 mGy), DLP 92.0 mGy·cm (73.7–107.6 mGy·cm), ED 0.61 mSv (0.52–0.69 mSv). Radiation exposure indices and effective and organ doses were significantly lower with third-generation DSCT ( P  < 0.001). Local DRLs could be set for CTDI vol at 0.75 mGy and DLP at 120 mGy·cm.

Conclusion: Third-generation DSCT requires significantly lower radiation dose for WBLDCT than second-generation DSCT and has an effective dose below reported doses for radiographic skeletal surveys. To ensure radiation protection, DRLs regarding WBLDCT are required, where our locally determined values may help as benchmarks.