Rodent Models to Analyze the Glioma Microenvironment

Animal models are still indispensable for understanding the basic principles of glioma development and invasion. Preclinical approaches aim to analyze the treatment efficacy of new drugs before translation into clinical trials is possible. Various animal disease models are available, but not every approach is useful for addressing specific questions. In recent years, it has become increasingly evident that the tumor microenvironment plays a key role in the nature of glioma. In addition to providing an overview, this review evaluates available rodent models in terms of usability for research on the glioma microenvironment.

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Date Issued:
19.04.2021
URN:
urn:nbn:de:hbz:464-20210607-094400-9
DOI:
10.1177/17590914211005074
Language:
English
Type of Resource:
Text
Keywords:
tumor microenvironment; glioma; rodent model; brain tumor; synthetic biology; preclinical oncology
Collection:
E-Publications
Subject categories of the Deutsche Nationalbibliografie:
610 Medical sciences Medicine
Hosting institution:
Faculty of Medicine, Essen University Hospital, Clinic for Neurosurgery
Hosting institution:
Faculty of Medicine, Essen University Hospital, Institute of Medical Psychology
funding:

The publication of this article was supported by the Publication Fund of the University of Duisburg-Essen.

Info on primary publication:

Hetze S, Sure U, Schedlowski M, Hadamitzky M, Barthel L. Rodent Models to Analyze the Glioma Microenvironment. ASN Neuro. January 2021. doi:10.1177/17590914211005074

Article first published online: April 19, 2021

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