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Nitric Oxide Generating Formulation as an Innovative Approach to Topical Skin Care : an Open-Label Pilot Study

Nitric oxide (NO) plays multiple roles in both normal and abnormal skin processes. Its deranging disbalance is involved in the pathogenesis of multiple dermatologic diseases such as acne vulgaris, pointing towards beneficial therapeutic directions. A novel NO-producing gel-formulation was tested beneficial in the treatment of acne vulgaris in an open-label pilot study using clinical evaluation scores. It showed a decrease of comedones and inflammatory pustulae and reduced the Global Acne Grading System score by 50% within eight weeks. In addition, we demonstrate a potential use as cosmetic agent where NO therapy leads to an increase of skin integrity and a reduction of skin ageing processes.

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Date Issued:
16.02.2021
DOI:
10.3390/cosmetics8010016
URN:
urn:nbn:de:hbz:464-20210416-114655-3
Language:
English
Type of Resource:
Text
Keywords:
nitric oxide; NO; acne vulgaris; topical therapy; skin ageing
Collection:
E-Publications
Subject categories of the Deutsche Nationalbibliografie:
610 Medical sciences Medicine
Hosting institution:
Faculty of Medicine, Essen University Hospital, Klinik für Kardiologie und Angiologie
Hosting institution:
Faculty of Medicine, Essen University Hospital, Clinic for Dermatology
funding:

The publication of this article was supported by the Publication Fund of the University of Duisburg-Essen.

Info on primary publication:

Settelmeier, S.; Rassaf, T.; Hendgen-Cotta, U.B.; Stoffels, I. Nitric Oxide Generating Formulation as an Innovative Approach to Topical Skin Care: An Open-Label Pilot Study. Cosmetics 2021, 8, 16. https://doi.org/10.3390/cosmetics8010016

Published: 16 February 2021

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