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Regulation of Beclin 1-Mediated Autophagy by Oncogenic Tyrosine Kinases

Beclin 1 is a major regulator of autophagy, and it is a core component of the class III PI3K complexes. Beclin 1 is a highly conserved protein and its function is regulated in a number of ways, including post-translational modifications. Several studies indicate that receptor and non-receptor tyrosine kinases regulate autophagy activity in cancer, and some suggest the importance of Beclin 1 tyrosine phosphorylation in this process. Here we summarize the current knowledge of the mechanism whereby some oncogenic tyrosine kinases regulate autophagy through Beclin 1.

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Date Issued:
03.12.2020
URN:
urn:nbn:de:hbz:464-20210211-123739-0
DOI:
10.3390/ijms21239210
Language:
English
Type of Resource:
Text
Keywords:
  1. Beclin 1
    Typ
    Schlagwort
  2. autophagy
    Typ
    Schlagwort
  1. tyrosine
    Typ
    Schlagwort
  1. kinases
    Typ
    Schlagwort
  1. cancer
    Typ
    Schlagwort
Subject categories of the Deutsche Nationalbibliografie:
610 Medical sciences Medicine
Hosting institution:
Faculty of Medicine, Essen University Hospital, Institute of Cell Biology (Tumor Research)
Hosting institution:
Faculty of Medicine, Essen University Hospital, Westdeutsches Tumorzentrum Essen (WTZ)
funding:

The publication of this article was supported by the Publication Fund of the University of Duisburg-Essen.

Info on primary publication:

Vega-Rubín-de-Celis, S.; Kinch, L.; Peña-Llopis, S. Regulation of Beclin 1-Mediated Autophagy by Oncogenic Tyrosine Kinases. Int. J. Mol. Sci. 2020, 21, 9210. https://doi.org/10.3390/ijms21239210

Published: 3 December 2020

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