Map3k14 as a Regulator of Innate and Adaptive Immune Response during Acute Viral Infection

Hamdan, Thamer A.; Bhat, Hilal; Cham, Lamin B.; Adomati, Tom;
GND
1213748321
ORCID
0000-0001-5352-106X
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, 45147 Essen, Germany, judith.lang@uk-essen.de
Lang, Judith; Li, Fanghui; Murtaza, Ali;
GND
1217605029
LSF
16157
Hardt, Cornelia;
GND
133631478
Lang, Philipp A.;
GND
1139721739
ORCID
0000-0002-6337-8225
Affiliation
Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia, vikas.duhan08@gmail.com
Duhan, Vikas; Lang, Karl S.

The replication of virus in secondary lymphoid organs is crucial for the activation of antigen-presenting cells. Balanced viral replication ensures the sufficient availability of antigens and production of cytokines, and both of which are needed for virus-specific immune activation and viral elimination. Host factors that regulate coordinated viral replication are not fully understood. In the study reported here, we identified Map3k14 as an important regulator of enforced viral replication in the spleen while performing genome-wide association studies of various inbred mouse lines in a model of lymphocytic choriomeningitis virus (LCMV) infection. When alymphoplasia mice (aly/aly, Map3k14aly/aly, or Nikaly/aly), which carry a mutation in Map3k14, were infected with LCMV or vesicular stomatitis virus (VSV), they display early reductions in early viral replication in the spleen, reduced innate and adaptive immune activation, and lack of viral control. Histologically, scant B cells and the lack of CD169+ macrophages correlated with reduced immune activation in Map3k14aly/aly mice. The transfer of wildtype B cells into Map3k14aly/aly mice repopulated CD169+ macrophages, restored enforced viral replication, and resulted in enhanced immune activation and faster viral control.

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Hamdan, T.A., Bhat, H., Cham, L.B., Adomati, T., Lang, J., Li, F., Murtaza, A., Hardt, C., Lang, P.A., Duhan, V., Lang, K.S., 2020. Map3k14 as a Regulator of Innate and Adaptive Immune Response during Acute Viral Infection. https://doi.org/10.3390/pathogens9020096
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