Simultaneous primary cancer occurrence of melanoma and pulmonary adenocarcinoma in leptomeningeal metastases : a case report

GND
1204609616
Affiliation
Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Stoppek, Ann-Kathrin;
GND
1035782421
Affiliation
Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Kebir, Sied;
GND
12978673X
Affiliation
Institute of Neuropathology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Junker, Andreas;
GND
1204608865
LSF
50603
Affiliation
Institute of Neuropathology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Keyvani, Kathy;
GND
1097389189
LSF
55474
Affiliation
Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Zülow, Stefan;
GND
1137839732
Affiliation
Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Lazaridis, Lazaros;
GND
1204609268
Affiliation
Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Schmidt, Teresa;
GND
174037228
Affiliation
West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Pierscianek, Daniela;
GND
116745961X
LSF
14603
Affiliation
Department of Radiotherapy, University Hospital Essen, Essen, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Stuschke, Martin;
GND
113528884
LSF
50510
Affiliation
West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Sure, Ulrich;
GND
123343909
LSF
58465
Affiliation
Department of Neurology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Kleinschnitz, Christoph;
GND
121203271
Affiliation
DKFZ Division of Translational Neurooncology at the West German Cancer Center (WTZ); German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.
Scheffler, Björn;
GND
131597914
LSF
54385
Affiliation
West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Zimmer, Lisa;
GND
129682543
ORCID
0000-0003-3167-3403
Affiliation
Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, University Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany. Martin.Glas@uk-essen.de.
Glas, Martin

Background: Leptomeningeal metastasis (LM) is a predominantly late stage, devastating complication of a variety of malignant solid tumors. Diagnosis relies predominantly on neurological, radiographic, and cerebrospinal fluid (CSF) assessments. Recently, liquid biopsy tests derived from CSF has shown to be a feasible, noninvasive promising approach to tumor molecular profiling for proper brain cancer diagnostic treatment, thereby providing an opportunity for CSF-based personalized medicine. However, LM is typically misleadingly assumed to originate from only one primary tumor type.

Case presentation: In this case report, we provide first evidence of the co-occurrence of LM originating from more than one primary tumor types.

Discussion and conclusions: Based on this patient case profile, the co-occurrence of LM from two or more primary tumor types should be accounted for when deriving diagnostic conclusions from liquid biopsy tests.

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