Tamoxifen Protects from Vesicular Stomatitis Virus Infection

GND
1217359680
ORCID
0000-0002-6855-5657
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. laminbcham@gmail.com.
Cham, Lamin B.;
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1162077468
VIAF
9676153126250124750000
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. Sarah-KimFriedrich@gmx.net.
Friedrich, Sarah-Kim;
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1205695176
VIAF
8376158369778701460004
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. Tom.Adomati@uk-essen.de.
Adomati, Tom;
GND
1217223169
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. bhathilal673@gmail.com.
Bhat, Hilal;
GND
1249932505
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. Maximilian-Schiller@web.de.
Schiller, Maximilian;
GND
1246847094
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. michael.bergerhausen@gmail.com.
Bergerhausen, Michael;
GND
1212813677
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. tamer_balaawi@yahoo.com.
Hamdan, Thamer A.;
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1214307922
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1925159613648041030007
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. fanghui.li@uni-due.de.
Li, Fanghui;
GND
1250454069
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. yaramachlah@yahoo.com.
Machlah, Yara Maria;
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. Murtaza142426@st.jmi.ac.in.
Ali, Murtaza;
GND
1139721739
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. Duhan.Vikas@uk-essen.de.
Duhan, Vikas;
GND
1201143713
LSF
52718
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. KarlSebastian.Lang@uk-essen.de.
Lang, Karl Sebastian;
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. Justa.Friebus-Kardash@uk-essen.de.
Friebus-Kardash, Justa;
Affiliation
Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany. Judith.Lang@uk-essen.de.
Lang, Judith

Background: Tamoxifen (TAM) is an estrogen-receptor antagonist, widely used in the adjuvant treatment of early stage estrogen-sensitive breast cancer. Several studies have revealed new biological targets of TAM that mediate the estrogen receptor independent activities of the drug. Recently, the antiviral activity of TAM on replication of human immunodeficiency virus (HIV), hepatitis C virus (HCV) and Herpes simplex virus (HSV-1) in vitro was described. In the current study, we aimed to investigate the effect of TAM on infection with vesicular stomatitis virus (VSV).

Methods: Vero cells were treated with different concentrations of TAM for 24 h and then infected with VSV. Additionally, C57BL/6 mice were pretreated with 4 mg TAM, one day and three days before infection with VSV.

Results: Treatment of Vero cells with TAM suppressed the viral replication of VSV in vitro and in vivo. The inhibitory effect of TAM on VSV replication correlated with an enhanced interferon-I response and stimulation of macrophages.

Conclusions: TAM was identified as being capable to protect from VSV infection in vitro and in vivo. Consequently, this antiviral function (as an advantageous side-effect of TAM) might give rise to new clinical applications, such as treatment of resistant virus infections, or serve as an add-on to standard antiviral therapy.

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