Postoperative Compensatory Ammonium Excretion Subsequent to Systemic Acidosis in Cardiac Patients

Roehrborn, Friederike; Dohle, Daniel-Sebastian; Waack, Indra Naemi; Tsagakis, Konstantinos LSF; Jakob, Heinz G. LSF; Teloh, Johanna Katharina

Background. Postoperative acid-base imbalances, usually acidosis, frequently occur after cardiac surgery. In most cases, the human body, not suffering fromany severe preexisting illnesses regarding lung, liver, and kidney, is capable of transient compensation and final correction.The aim of this study was to correlate the appearance of postoperatively occurring acidosis with renal ammonium excretion. Materials and Methods. Between 07/2014 and 10/2014, a total of 25 consecutive patients scheduled for elective isolated coronary artery bypass grafting with cardiopulmonary bypass were enrolled in this prospective observational study. During the operative procedure and the first two postoperative days, blood gas analyses were carried out and urine samples collected. Urine samples were analyzed for the absolute amount of ammonium. Results. Of all patients, thirteen patients developed acidosis as an initial disturbance in the postoperative period: five of respiratory and eight of metabolic origin. Four patients with respiratory acidosis but none of those with metabolic acidosis subsequently developed a base excess > +2mEq/L. Conclusion. Ammonium excretion correlated with the increase in base excess. The acidosis origin seems to have a large influence on renal compensation in terms of ammonium excretion and the possibility of an overcorrection.

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Roehrborn, Friederike / Dohle, Daniel-Sebastian / Waack, Indra Naemi / et al: Postoperative Compensatory Ammonium Excretion Subsequent to Systemic Acidosis in Cardiac Patients. 2017.

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