A non-interventional study of the genetic polymorphisms of NOD2 associated with increased mortality in non-alcoholic liver transplant patients
Methods: During a period of 20-months, 231 patients were recruited in this non-interventional, prospective study.Thirteen different SNPs and their impact on the patients’survival, infection rate, and use of dialysis were assessed.
Results: NOD 2 wildtype genes were protective with respect to the survival of non-alcoholic, cirrhotic transplant patients(3 year survival: 66.8% wildtype vs. 42.6% gene mutation, p = 0.026). This effect was not observed in alcoholic transplantrecipients.The incidence of dialysis-dependent kidney failure and infectioninthelivertransplantpatients was not influenced byNOD 2 gene polymorphisms. No effect was noted in the remaining 12 SNPs.Patients with early allograft dysfunction experienced significantly more infections, required dialysis and had significantlyworse survival.In contrast, the donor-risk-index had no impact on the infection rate, use of dialysis or survival.
Conclusion: NOD2 gene variants seem to play a key role in non-alcoholic, liver transplant recipients. However these datashould be validated in a larger cohort.
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