HLA-G as a Tolerogenic Molecule in Transplantation and Pregnancy

HLA-G is a nonclassical HLA class I molecule. In allogeneic situations such as pregnancy or allograft transplantation, the expression of HLA-G has been related to a better acceptance of the fetus or the allograft. Thus, it seems that HLA-G is crucially involved in mechanisms shaping an allogeneic immune response into tolerance. In this contribution we focus on (i) how HLA-G is involved in transplantation and human reproduction, (ii) how HLA-G is regulated by genetic and microenvironmental factors, and (iii) how HLA-G can offer novel perspectives with respect to therapy.

Preview

Category

Date Issued:
21.07.2014
URN:
urn:nbn:de:hbz:464-20160512-115716-1
DOI:
10.1155/2014/297073
Language:
English
Type of Resource:
Text
Collection:
E-Publications
Dewey Decimal Classification:
610 Medicine & health
Subject categories of the Deutsche Nationalbibliografie:
610 Medical sciences Medicine
Hosting institution:
Faculty of Medicine, Essen University Hospital, Institute of Transfusion Medicine
Info on primary publication:
Journal of Immunology Research, Volume 2014 (2014), Article ID 297073, 16 pages;
Published 21 Jul 2014
funding:

The publication of this article was supported by the Publication Fund of the University of Duisburg-Essen.

Cite

Citation style:
Could not load citation form.

Rights

Use and reproduction:
This work may be used under a
CC BY 3.0 LogoCreative Commons Attribution 3.0 License (CC BY 3.0)
.