Context, connection, and co-ordination: the need to switch

Commentary on: Phillips, W., & Silverstein, S. (2003). "Convergence of biological and psychological perspectives on cognitive coordination in schizophrenia." Behavioral and Brain Sciences, 26(1), 65-82.


Context, connection, and coordination (CCC) describe well where the problems that apply to thought-disordered patients with schizophrenia lie. But they may be part of the experience of those with other symptom constellations. Switching is an important mechanism to allow context to be applied appropriately to changing circumstances. In some cases, NMDA-voltage modulations may be central, but gain and shift are also functions that monoaminergic systems express in CCC.


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