Signs of differential stimulus processing problems : a comment on event-related potentials in young schizophrenic and autistic subjects

A comparison of the Nd (negative difference ERP) in a 3-tone auditory oddball paradigm (task-minus-nontask conditions) for a 16 y-old healthy adolescent with a 16y-old patient with paranoid schizophrenia. Early (100-200 ms) and late Nd components (200-300 ms) were reduced in amplitude and shifted in topography centromedially in the patient. While we have recorded a similar impairment in schizoaffective patients, this problem was not evident in disorganised schizophrenia or OCD. Indeed, no impairment of Nd amplitude was observed in a comparison of 7 healthy children with 7 patients with childhood autism.


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