@Article{duepublico_mods_00082405,
  author = 	{Richlitzki, Cedric
		and Wiesweg, Marcel
		and Metzenmacher, Martin
		and Guberina, Nika
		and P{\"o}ttgen, Christoph
		and Hautzel, Hubertus
		and Eberhardt, Wilfried E. E.
		and Darwiche, Kaid
		and Theegarten, Dirk
		and Aigner, Clemens
		and B{\"o}l{\"u}kbas, Servet
		and Schuler, Martin
		and Stuschke, Martin
		and Guberina, Maja},
  title = 	{C-reactive protein as robust laboratory value associated with prognosis in patients with stage III non-small cell lung cancer (NSCLC) treated with definitive radiochemotherapy},
  year = 	{2024},
  month = 	{Jun},
  day = 	{14},
  keywords = 	{C-reactive protein (CRP); Stage III non-small cell lung cancer (NSCLC); Definitive radiochemotherapy; Laboratory values; Overall survival; ESPATUE trial},
  abstract = 	{To evaluate the prognostic value of biomarkers from peripheral blood obtained as routine laboratory assessment for overall survival in a cohort of stage III non-small cell lung cancer (NSCLC) patients treated with definitive radiochemotherapy at a high-volume cancer center. Seven blood biomarkers from 160 patients treated with definitive radiochemotherapy for stage III NSCLC were analyzed throughout the course treatment. Parameters were preselected using univariable and multivariable proportional hazards analysis and were assessed for internal validity using leave-one-out cross validation. Cross validated classifiers including biomarkers in addition to important clinical parameters were compared with classifiers containing the clinical parameters alone. An increased C-reactive protein (CRP) value in the final week of radiotherapy was found as a prognostic factor for overall survival, both as a continuous (HR 1.099 (1.038--1.164), p{\thinspace}<{\thinspace}0.0012) as well as categorical variable splitting data at the median value of 1.2 mg/dl (HR 2.214 (1.388--3.531), p{\thinspace}<{\thinspace}0.0008). In the multivariable analysis, the CRP value-maintained significance with an HR of 1.105 (1.040--1.173) and p-value of 0.0012. The cross validated classifier using CRP at the end of radiotherapy in addition to clinical parameters separated equally sized high and low risk groups more distinctly than a classifier containing the clinical parameters alone (HR{\thinspace}={\thinspace}2.786 (95{\%} CI 1.686--4.605) vs. HR{\thinspace}={\thinspace}2.287 (95{\%} CI 1.407--3.718)). Thus, the CRP value at the end of radiation therapy has successfully passed the crucial cross-validation test. The presented data on CRP levels suggests that inflammatory markers may become increasingly important during definitive radiochemotherapy, particularly with the growing utilization of immunotherapy as a consolidation therapy for stage III NSCLC.},
  note = 	{<p>Open Access funding enabled and organized by Projekt DEAL.</p>},
  note = 	{<p>Richlitzki, C., Wiesweg, M., Metzenmacher, M. <em>et al.</em> C-reactive protein as robust laboratory value associated with prognosis in patients with stage III non-small cell lung cancer (NSCLC) treated with definitive radiochemotherapy. <em>Sci Rep</em> <strong> 14</strong>, 13765 (2024). <a href="https://doi.org/10.1038/s41598-024-64302-2">https://doi.org/10.1038/s41598-024-64302-2</a></p>

<p>Published: 14 June 2024</p>},
  note = 	{Version of Record / Verlagsversion},
  doi = 	{10.1038/s41598-024-64302-2},
  url = 	{https://duepublico2.uni-due.de/receive/duepublico_mods_00082405},
  url = 	{https://doi.org/10.1038/s41598-024-64302-2},
  file = 	{:https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00082671/Sci_Rep_2024_14_13765.pdf:PDF},
  language = 	{en}
}