Throughout the COVID-19 crisis, scientists around the globe have engaged in science communication to an unprecedented degree to convey first-hand epidemiological knowledge and information on preventive measures. The present work is aimed at empirically investigating the impact of direct exposure to scientists as compared to general COVID-19-related media consumption (N = 698) on central cognitive, affective, and behavioral variables, based on the extended parallel process model (EPPM) and its adaptations. A segment of the sample comprises individuals recruited independently, while others were sourced from an online panel. Importantly, this study sample was conducted at the outset of the COVID-19 pandemic. The results revealed that direct exposure to scientists positively affected recipients’ knowledge and self-efficacy. General media consumption, by contrast, positively affected perceived threat as well as fear and uncertainty. Both sources positively affected the adherence to protective measures.