@Article{duepublico_mods_00082010, author = {Feng, Huayang and Linders, J{\"u}rgen and Cantore, Miriam and Fabrizi, Jonas and Kirsten, Annika and Myszkowska, Sascha and Hillen, Eva and Uteschil, Florian and Buchholz, Sebastian and Hermsen, Andrea and Garvin, Maria Davila and Ferenz, Katja Bettina and Mayer, Christian}, title = {Cross-linked Triblock Peptide Capsules as Potential Oxygen Carriers}, year = {2024}, month = {Mar}, day = {12}, abstract = {Perfluorodecalin (PFD)-filled capsules have been studied for over 15 years as artificial oxygen carriers. However, none of these capsules combines good biocompatibility, good mechanical stability and dispersion stability. Here we propose to use synthetic triblock peptides containing a central block of cysteine units as a cross-linking shell material for capsules with both good biocompatibility and stability. Together with outer aspartate units and inner phenylalanine units, the resulting amphiphilic triblock peptides can encapsulate PFD efficiently to prepare capsules with a suitable diameter, a certain mechanical strength, a large diffusion constant, fast gas exchange rates, and little cytotoxicity. Given the above advantages, these PFD-filled peptide capsules are very promising as potential artificial oxygen carriers.}, note = {<p>The publication of this article was supported by the Publication Fund of the University of Duisburg-Essen.</p> <p>Open Access funding enabled and organized by Projekt DEAL.</p>}, note = {<p>H. Feng, J. Linders, M. Cantore, J. Fabrizi, A. Kirsten, S. Myszkowska, E. Hillen, F. Uteschil, S. Buchholz, A. Hermsen, M. D. Garvin, K. B. Ferenz, C. Mayer, <em>ChemistryOpen</em> 2024, 13, e202300282. <a href="https://doi.org/10.1002/open.202300282">https://doi.org/10.1002/open.202300282</a></p> <p>Version of record online: March 12, 2024</p>}, note = {Version of Record / Verlagsversion}, doi = {10.1002/open.202300282}, url = {https://duepublico2.uni-due.de/receive/duepublico_mods_00082010}, url = {https://doi.org/10.1002/open.202300282}, file = {:https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00082016/ChemistryOpen_2024_e202300282.pdf:PDF}, language = {en} }