000K  utf8
1100  2024$c2024-02-27
1500  eng
2050  urn:nbn:de:hbz:465-20240806-143333-5
2051  10.3390/v16030364
3000  Karakoese, Zehra
3010  Dittmer, Ulf
3010  Ingola, Martha
3010  Sitek, Barbara
3010  Sutter, Kathrin
4000  IFNα Subtypes in HIV Infection and Immunity  [Karakoese, Zehra]
4209  Type I interferons (IFN), immediately triggered following most viral infections, play a pivotal role in direct antiviral immunity and act as a bridge between innate and adaptive immune responses. However, numerous viruses have evolved evasion strategies against IFN responses, prompting the exploration of therapeutic alternatives for viral infections. Within the type I IFN family, 12 IFNα subtypes exist, all binding to the same receptor but displaying significant variations in their biological activities. Currently, clinical treatments for chronic virus infections predominantly rely on a single IFNα subtype (IFNα2a/b). However, the efficacy of this therapeutic treatment is relatively limited, particularly in the context of Human Immunodeficiency Virus (HIV) infection. Recent investigations have delved into alternative IFNα subtypes, identifying certain subtypes as highly potent, and their antiviral and immunomodulatory properties have been extensively characterized. This review consolidates recent findings on the roles of individual IFNα subtypes during HIV and Simian Immunodeficiency Virus (SIV) infections. It encompasses their induction in the context of HIV/SIV infection, their antiretroviral activity, and the diverse regulation of the immune response against HIV by distinct IFNα subtypes. These insights may pave the way for innovative strategies in HIV cure or functional cure studies.
4950  https://doi.org/10.3390/v16030364$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:hbz:465-20240806-143333-5$xR$3Volltext$534
4961  https://duepublico2.uni-due.de/receive/duepublico_mods_00081724
5051  610
5550  HIV
5550  IFNα subtypes
5550  immunotherapy
5550  type I IFNs