000K utf8 1100 2023$c2023-08-04 1500 eng 2050 urn:nbn:de:hbz:465-20240725-172618-9 2051 10.1002/jvc2.231 3000 Placke, Jan-Malte 3010 Becker, Jürgen C. 3010 Hadaschik, Eva 3010 Krefting, Frederik 3010 Livingstone, Elisabeth 3010 Lodde, Georg C. 3010 Roesch, Alexander 3010 Schadendorf, Dirk 3010 Srinivas, Nalini K. 3010 Sucker, Antje 3010 Tasdogan, Alpaslan 3010 Ugurel, Selma 3010 Zahn, Maximilian 3010 Zillikens, Hannah 3010 Zimmer, Lisa 4000 Prognostic factors in the primary care of patients with Merkel cell carcinoma$dA monocentric cohort study of 108 patients from a tertiary referral centre [Placke, Jan-Malte] 4209 Background: Merkel cell carcinoma (MCC) is one of the deadliest skin cancers. Despite existing national guidelines, treatment of MCC patients is not as well standardized as for more common skin cancers. Objectives: The study objective was to investigate factors predisposing to favourable/unfavourable patient outcomes and to which extent guideline-based care affects patient survival. Methods: This noninterventional study investigated a monocentre real-world patient cohort with a histologically confirmed diagnosis of MCC who presented at the skin cancer centre, University Hospital Essen. Patient and tumour characteristics (age, sex, primary localization, Merkel cell polyomavirus [MCPyV], tumour stage at initial diagnosis and primary treatment measures [surgery, radiation]) were correlated with the patient outcome in terms of recurrence-free survival (RFS) and overall survival (OS). Results: A total of 108 patients were identified. The median age of the patients was 69.9 years (range 39–88), with patients aged <70 years showing a trend towards a longer RFS (p = 0.192). Regarding sex, 69 (63.9%) of the patients were male, with females showing a trend towards a longer RFS (0.189). MCPyV+ primary tumours are less frequently located in the head/neck region (p = 0.003). Patients with primary tumours in the head/neck region had a significantly worse OS than patients with primary tumours at the trunk/extremities (p = 0.007). Patients with positive sentinel lymph nodes (SLNs) showed a tendency towards shorter RFS (p = 0.126) and OS (p = 0.089). Patients with American Joint Committee on Cancer stages I, IIA and IIB had a slightly better RFS (p = 0.803) and OS (p = 0.820) compared to patients with stages IIIA and IIIB. Moreover, the administration of adjuvant radiotherapy resulted in a slightly better RFS (p = 0.299) and OS (p = 0.276) in patients with tumour stages I, IIA and IIB. Conclusions: In the present study, the outcome of MCC patients depended on primary tumour localization, SLN status, sex and age. The tumour stage and the adjuvant radiation had only limited effects on patient outcomes. 4950 https://doi.org/10.1002/jvc2.231$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:hbz:465-20240725-172618-9$xR$3Volltext$534 4961 https://duepublico2.uni-due.de/receive/duepublico_mods_00081510 5051 610 5550 epidemiology 5550 Merkel cell carcinoma