LCP-tacrolimus in long-term kidney graft recipients : Dosing and adherence

Introduction: The new LCP-formulation of tacrolimus (Tac) has shown pharmacokinetic advantages in patients after liver transplantation that are associated with better adherence. The influence of prolonged release Tac on adherence, trough levels and dosing of Tac remains unclear.
 
Methods: A prospective study was performed in 62 patients from two centers, who were switched to LCP-Tac after kidney transplantation, to assess adherence as defined by the Tac trough level coefficient of variation (CoV) (primary endpoint) and BAASIS© Score, as well as kidney function, Tac trough level and tacrolimus dose.
 
Results: BAASIS© Score and Tac trough level CoV demonstrated good adherence over the study period, with no difference between the study timepoints (0.26 ± 0.16 at study start and 0.26 ± 0.11 at study end, p = 0.976, paired t-test). Graft function and Tac trough levels remained stable, and Tac dose could be reduced. 
 
Conclusions: A switch to LCP-Tac is feasible and leads to stable adherence, graft function and Tac trough levels, in combination with lower Tac doses.

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Date Issued:
18.05.2023
URN:
urn:nbn:de:hbz:465-20230828-154443-1
DOI:
10.1016/j.tpr.2023.100139
Language:
English
Type of Resource:
Text
Keywords:
TacrolimusGND; Kidney transplantation; Adherence; Trough level; Coefficient of variation; LCP
Collection:
E-Publications
Subject categories of the Deutsche Nationalbibliografie:
610 Medical sciences Medicine
Hosting institution:
Faculty of Medicine, Essen University Hospital, Zentrum für Kinder- und Jugendmedizin, Klinik für Kinderheilkunde II
funding:

The publication of this article was supported by the Publication Fund of the University of Duisburg-Essen.

Info on primary publication:

Schill, Y., Schiffer, M., & Pape, L. (2023). LCP-tacrolimus in long-term kidney graft recipients: Dosing and adherence. Transplantation Reports, 8(3):100139. https://doi.org/10.1016/j.tpr.2023.100139

Available online 18 May 2023

version identification:
Version of Record / Verlagsversion

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