000K utf8 1100 2023$c2023-05-28 1500 eng 2050 urn:nbn:de:hbz:465-20230810-183635-5 2051 10.1016/j.ijcha.2023.101230 3000 Ilias, Christos 3010 Ayoub, George 3010 Kamler, Markus 3010 Koch, Achim 3010 Lainka, Martin 3010 Luedike, Peter 3010 Papathanasiou, Maria 3010 Pizanis, Nikolaos 3010 Rassaf, Tienush 3010 Ruhparwar, Arjang 3010 Schmack, Bastian 4000 Vascular complications after peripheral veno-arterial extracorporeal life support cannulation in cardiogenic shock [Ilias, Christos] 4209 Background: Extra Corporeal Life Support(ECLS) is an evolving therapy in therapy-resistant cardiogenic shock(CS). Vascular cannulation in emergency situations can be accomplished through puncture of the femoral vessels by specialised teams. Since lower limb ischemia constitutes one of the major complications following cannulation, a distal perfusion cannula (DPC) has emerged as standard of care. We here aimed to analyse the impact of the DPC on limb perfusion and 6-month survival rate. Methods: In a retrospective study from January 2012 to December 2018, 98 patients with cardiogenic shock and peripheral (v-a) ECLS implantation with documented limb perfusion status were identified and analysed. Demographic data, laboratory parameters, cause of CS, comorbidities, limb perfusion complications and complication management were analysed. Results: 53 patients (54%) received ECLS therapy in referral centers by our mobile ECLS team, while in 45 patients (46%) the cannulation occured in our center. 71 patients (72%) received a DPC (group A) at the time of ECLS implantation, whereas 27 (28%) (group B) did not or received later (14 patients owing to limb ischemia). 44 patients (45%) developed limb ischemia as a complication of ECLS therapy (31% in group A and 81% in group B- p < 0.001). The 6-month survival rate was 28% in our Conclusion: Lower limb ischemia remains a serious complication after peripheral ECLS cannulation in CS, especially when a DPC is absent. Standardised DPC implementation may reduce the rate of severe limb complications in peripheral ECLS. 4950 https://doi.org/10.1016/j.ijcha.2023.101230$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:hbz:465-20230810-183635-5$xR$3Volltext$534 4961 https://duepublico2.uni-due.de/receive/duepublico_mods_00078537 5051 610 5550 Cardiogenic shock 5550 Distal perfusion cannula 5550 Extracorporeal life support 5550 Lower limb ischemia