000K utf8 1100 2023$c2023-03-29 1500 eng 2050 urn:nbn:de:hbz:465-20230822-145300-8 2051 10.3390/jcm12072585 3000 Said, Maryam 3010 Ahmadipour, Yahya 3010 Chihi, Mehdi 3010 Dammann, Philipp 3010 Darkwah Oppong, Marvin 3010 Dinger, Thiemo F. 3010 Gümüs, Meltem 3010 Jabbarli, Ramazan 3010 Rauschenbach, Laurèl 3010 Rodemerk, Jan 3010 Sure, Ulrich 3010 Wrede, Karsten 4000 Morphometric Study of the Initial Ventricular Indices to Predict the Complications and Outcome of Aneurysmal Subarachnoid Hemorrhage [Said, Maryam] 4209 Objective: Acute hydrocephalus is a common complication in patients with aneurysmal subarachnoid hemorrhage (SAH). Several ventricular indices have been introduced to enable measurements of ventricular morphology. Previously, researchers have showed their diagnostic value for various neurological disorders. In this study, we evaluated the association between ventricular indices and the clinical course, occurrence of complications and outcome of SAH. Methods: A total of 745 SAH patients with available early admission computed tomography scans were included in the analyses. Six ventricular indices (bifrontal, bicaudate, ventricular and third ventricle ratios and Evans’ and Huckman’s indices) were measured. Primary endpoints included the occurrence of cerebral infarctions, in-hospital mortality and a poor outcome at 6 months. Secondary endpoints included different adverse events in the course of SAH. Clinically relevant cut-offs for the indices were determined using receiver operating curves. Univariate analyses were performed. Multivariate analyses were conducted on significant findings in a stepwise backward regression model. Results: The higher the values of the ventricular indices were and the older the patient was, the higher the WFNS and Fisher’s scores were, and the lower the SEBES score was at admission. Patients with larger ventricles showed a shorter duration of intracranial pressure increase > 20 mmHg and required decompressive craniectomy less frequently. Ventricular indices were independently associated with the parameters of inflammatory response after SAH (C-reactive protein in serum and interleukin-6 in cerebrospinal fluid and fever). Finally, there were independent correlations between larger ventricles and all the primary endpoints. Conclusions: The lower risk of intracranial pressure increase and absence of an association with vasospasm or systemic infections during SAH, and the poorer outcome in individuals with larger ventricles might be related to a more pronounced neuroinflammatory response after aneurysmal bleeding. These observations might be helpful in the development of specific medical and surgical treatment strategies for SAH patients depending on the initial ventricle measurements. 4950 https://doi.org/10.3390/jcm12072585$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:hbz:465-20230822-145300-8$xR$3Volltext$534 4961 https://duepublico2.uni-due.de/receive/duepublico_mods_00078349 5051 610 5550 decompressive craniectomy 5550 inflammation 5550 marker 5550 subarachnoid hemorrhage 5550 ventricular measurements