@Article{duepublico_mods_00078028,
  author = 	{Rashidi-Alavijeh, Jassin
		and Kahraman, Alisan
		and Gerken, Guido
		and Theysohn, Jens M.
		and Willuweit, Katharina
		and Hoyer, Dieter P.
		and Lange, Christian M.
		and Buechter, Matthias},
  title = 	{Enzymatic liver function measured by LiMAx is superior to current standard methods in predicting transplant-free survival after TIPS implantation},
  year = 	{2021},
  month = 	{Jul},
  day = 	{05},
  keywords = 	{Liver cirrhosis; Portal hypertension},
  abstract = 	{Transjugular intrahepatic portosystemic shunt (TIPS) is one of the main treatment options in patients with decompensated liver cirrhosis but is still associated with partly severe complications. For adequate patient selection, prognostic parameters are of crucial importance. The liver maximum capacity (LiMAx) breath test measures enzymatic liver function and could potentially represent an efficient prognostic marker. We therefore aimed to assess the role of LiMAx in predicting survival of TIPS patients in a prospective analysis. LiMAx was performed for patients who underwent TIPS implantation between October 2016 and February 2018. Associations with transplant-free survival after 24 weeks were assessed by logistic regression. A total number of 30 patients were included, of whom seven received liver transplantation (N{\thinspace}={\thinspace}2) or died (N{\thinspace}={\thinspace}5) during follow-up. LiMAx values after ( P {\thinspace}={\thinspace}0.01, OR{\thinspace}={\thinspace}1.24, 95{\%} CI{\thinspace}={\thinspace}1.04--1.47) and before ( P {\thinspace}={\thinspace}0.03, OR 1.21, 95{\%} CI{\thinspace}={\thinspace}1.02--1.43) TIPS implantation and MELD score ( P {\thinspace}={\thinspace}0.03, OR{\thinspace}={\thinspace}0.79, 95{\%} CI{\thinspace}={\thinspace}0.63--0.98) were significantly associated with transplant-free survival according to univariate logistic regression. In AUROC analysis, LiMAx at day one after TIPS (sensitivity 85.7{\%}, specificity 78.3{\%}, AUROC 0.85, cut-off ≤{\thinspace}165 {\textmu}g/kg/h), LiMAx value at the day before TIPS (sensitivity 100{\%}, specificity 73.9{\%}, AUROC 0.82, cut-off ≤{\thinspace}205 {\textmu}g/kg/h) and MELD score (sensitivity 71.4{\%}, specificity 73.9{\%}, AUROC 0.82, cut-off ≥{\thinspace}15) had the highest prognostic accuracy. LiMAx values prior and after TIPS procedure seem to be good prognostic parameters regarding prediction of transplant-free survival of patients undergoing TIPS implantation.},
  note = 	{<p>The publication of this article was supported by the Publication Fund of the University of Duisburg-Essen.</p>

<p>Open Access funding enabled and organized by Projekt DEAL.</p>},
  note = 	{<p>Rashidi-Alavijeh, J., Kahraman, A., Gerken, G. <em>et al.</em> Enzymatic liver function measured by LiMAx is superior to current standard methods in predicting transplant-free survival after TIPS implantation. <em>Sci Rep</em> <strong> 11</strong>, 13834 (2021). <a href="https://doi.org/10.1038/s41598-021-93392-5">https://doi.org/10.1038/s41598-021-93392-5</a></p>

<p>Published 05 July 2021</p>},
  note = 	{Version of Record / Verlagsversion},
  doi = 	{10.1038/s41598-021-93392-5},
  url = 	{https://duepublico2.uni-due.de/receive/duepublico_mods_00078028},
  url = 	{https://doi.org/10.1038/s41598-021-93392-5},
  file = 	{:https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00077673/Sci_Rep_2021_11_13834.pdf:PDF},
  language = 	{en}
}