000K  utf8
1100  2021$c2021-01-22
1500  eng
2050  urn:nbn:de:hbz:465-20240827-092341-6
2051  10.1038/s41598-021-81502-2
3000  Kleine-Borgmann, Julian
3010  Billinger, Marieke
3010  Bingel, Ulrike
3010  Forkmann, Katarina
3010  Schmidt, Katharina
3010  Wiech, Katja
4000  Effects of open-label placebos on test performance and psychological well-being in healthy medical students$da randomized controlled trial  [Kleine-Borgmann, Julian]
4209  Psychological distress is prevalent in students and can predispose to psychiatric disorders. Recent findings indicate that distress might be linked to impaired cognitive performance in students. Experimental findings in healthy participants suggest that placebo interventions can improve cognition. However, whether non-deceptive (i.e., open-label, OLP) placebos can enhance cognitive function and emotional well-being is unclear. Using a randomized-controlled design we demonstrate a positive impact of OLP on subjective well-being (i.e., stress, fatigue, and confusion) after a 21-day OLP application in healthy students during midterm exams. OLP did not improve test performance, but, within the OLP group, test performance was positively correlated with measures of general belief in the benefit of medication. These results show that OLP can counteract negative effects of acute stress on psychological well-being and might improve cognitive performance if supported by positive treatment expectations. Additionally, our findings in healthy volunteers warrant further investigation in exploring the potential of OLP in reducing stress-related psychological effects in patients.
4950  https://doi.org/10.1038/s41598-021-81502-2$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:hbz:465-20240827-092341-6$xR$3Volltext$534
4961  https://duepublico2.uni-due.de/receive/duepublico_mods_00077937
5051  610
5550  Cognitive neuroscience
5550  Fatigue
5550  Human behaviour
5550  Stress and resilience