@Article{duepublico_mods_00077609,
  author = 	{Farzaliyev, Farhad
		and Touma, Alexander
		and Taeger, Georg
		and Steinau, Hans-Ulrich
		and Hardes, Jendrik
		and Streitb{\"u}rger, Arne
		and Podleska, Lars Erik},
  title = 	{Efficacy of hyperthermic isolated limb perfusion in the treatment of locally recurrent high-grade soft tissue sarcoma of the extremities},
  year = 	{2020},
  month = 	{Dec},
  day = 	{21},
  abstract = 	{Background: This novel study compared the use of tumor necrosis factor (TNF)-alpha and melphalan-based isolated limb perfusion (TM-ILP) to the standard treatment of locally recurrent soft tissue extremity sarcoma. The aim was to assess whether TM-ILP positively influences the recurrence-free survival of locally recurrent high-grade soft tissue sarcoma (STS) of the extremities. Methods: We retrospectively analyzed our clinical database for patients with STS. Variables were analyzed using chi-square test or Mann-Whitney rank-sum test. Furthermore, Kaplan-Meier survival plots were calculated and a proportional hazard regression model was developed. Results: Out of 448 patients with extraabdominal STS treated between August 2012 and December 2015, 52 cases involving 47 patients had locally recurrent STS. Twenty-eight of these patients were treated with TM-ILP prior to surgical resection (TM-ILP-group), and 24 were treated with standard therapy (without TM-ILP). The 3-year recurrence-free survival for the TM-ILP-group was estimated at 75{\%} (95{\%} confidence interval (CI), 71.5--78.5). Local recurrence-free survival in the standard group was significantly lower (LRFS: 43.4{\%}, 95{\%} CI 38.7--48.1, p = 0.026). Multivariable analysis revealed resection with negative margins, lower number of previous recurrences, and TM-ILP as positive predictors for recurrence-free survival. Conclusions: TM-ILP and consecutive resection of residual tumor with negative resection margins significantly improves local recurrence-free survival for patients with a first local recurrence of high-grade STS in the extremities.},
  note = 	{<p>The publication of this article was supported by the Publication Fund of the University of Duisburg-Essen.</p>

<p>Open Access funding enabled and organized by Projekt DEAL.</p>},
  note = 	{<p>Farzaliyev, F., Touma, A., Taeger, G. <em>et al.</em> Efficacy of hyperthermic isolated limb perfusion in the treatment of locally recurrent high-grade soft tissue sarcoma of the extremities. <em>World J Surg Onc</em> <strong> 18</strong>, 332 (2020). <a href="https://doi.org/10.1186/s12957-020-02110-4">https://doi.org/10.1186/s12957-020-02110-4</a></p>

<p>Published 21 December 2020</p>},
  note = 	{Version of Record / Verlagsversion},
  doi = 	{10.1186/s12957-020-02110-4},
  url = 	{https://duepublico2.uni-due.de/receive/duepublico_mods_00077609},
  url = 	{https://doi.org/10.1186/s12957-020-02110-4},
  file = 	{:https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00077260/World_J_Surg_Onc_2020_18_332.pdf:PDF},
  language = 	{en}
}