000K  utf8
1100  2021$c2021-02-11
1500  eng
2050  urn:nbn:de:hbz:465-20240828-111439-0
2051  10.1186/s12959-021-00263-0
3000  Boss, Kristina
3010  Kribben, Andreas
3010  Tyczynski, Bartosz
4000  Pathological findings in rotation thromboelastometry associated with thromboembolic events in COVID-19 patients  [Boss, Kristina]
4209  Background: Severe thromboembolic events are one of the major complications associated with COVID-19 infection, especially among critically ill patients. We analysed ROTEM measurements in COVID-19 patients with a severe disease course and in patients with severe sepsis. Methods: In this study, data obtained by extended analysis of haemostasis with standard laboratory tests and thromboelastometry of 20 patients with severe course of COVID-19 were retrospectively analysed and compared with similar data from 20 patients with severe sepsis but no COVID-19. Results: The thromboelastometry values obtained from 20 sepsis patients contained a maximum clot firmness above the normal range but among COVID-19 patients, hypercoagulability was much more pronounced, with significantly higher maximum clot firmness (FIBTEM: 38.4 ± 10.1 mm vs. 29.6 ± 10.8 mm; P  = 0.012; EXTEM: 70.4 ± 10.4 mm vs. 60.6 ± 14.8 mm; P  = 0.022). Additionally, fibrinogen levels were significantly higher among COVID-19 patients (757 ± 135 mg/dl vs. 498 ± 132 mg/dl, P  < 0.0001). Furthermore, thromboelastometry showed fibrinolysis shutdown among COVID-19 patients with significantly lower maximum of lysis than among sepsis patients (EXTEM: 0.6 ± 1.2 % vs. 3.3 ± 3.7 %; P  = 0.013). Seven of 20 COVID-19 patients experienced thromboembolic events, whereas no patient in the sepsis group experienced such events. Conclusions: ROTEM analysis showed significantly different pathological findings characterized by hypercoagulability and fibrinolysis shutdown among COVID-19 patients with a severe disease course compared to patients with severe sepsis. These abnormalities seem to be associated with thromboembolic events.
4950  https://doi.org/10.1186/s12959-021-00263-0$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:hbz:465-20240828-111439-0$xR$3Volltext$534
4961  https://duepublico2.uni-due.de/receive/duepublico_mods_00077579
5051  610
5550  COVID-19
5550  ROTEM®
5550  Sepsis
5550  Thromboelastometry
5550  Thromboembolic event