000K utf8 1100 2020$c2020-12-01 1500 eng 2050 urn:nbn:de:hbz:465-20240815-161603-5 2051 10.1186/s13052-020-00939-9 3000 Bruns, Nora 3010 Dohna-Schwake, Christian 3010 Felderhoff-Müser, Ursula 3010 Gratopp, Alexander 3010 Große Lordemann, Anja 3010 Heitmann, Friedhelm 3010 Hoppen, Thomas 3010 Hoppenz, Marc 3010 Krüger, Marcus 3010 Löffler, Günther 3010 Meyburg, Jochen 3010 Rasche, Tobias 3010 Wieg, Christian 4000 Iatrogenic severe hyperglycemia due to parenteral administration of glucose in children$da case series [Bruns, Nora] 4209 Background: Iatrogenic severe hyperglycemia (ISH) caused by glucose-containing i.v. solution is a potentially fatal treatment error. The objective of this study was to investigate the causes, circumstances, course of disease, and complications of ISH > 300 mg/dl (16.7 mmol/l) in neonates and children. Methods: We emailed a survey to 105 neonatal and pediatric intensive care units in Germany, Austria, and Switzerland, asking to retrospectively report cases of ISH. Results: We received 11 reports about premature infants to children. Four patients (36%) had poor outcome: 2 died and 2 suffered persistent sequelae. The highest observed blood glucose was at median 983 mg/dl (54.6 mmol/l) (range 594–2240 mg/dl; 33.0–124.3 mmol/l) and median time to normoglycemia was 7 h (range 2–23). Blood glucose was higher and time to normoglycemia longer in patients with poor outcome. Invasive therapy was required in 73% (mechanical ventilation) and 50% (vasopressor therapy) of patients, respectively. Administration of insulin did not differ between outcome groups. Patients with poor outcome showed coma (100% vs. 40%) and seizures (75% vs. 29%) more frequently than those with good outcome. Conclusions: ISH is a severe condition with high morbidity and mortality. Further research to amplify the understanding of this condition is needed, but focus should largely be held on its prevention. 4950 https://doi.org/10.1186/s13052-020-00939-9$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:hbz:465-20240815-161603-5$xR$3Volltext$534 4961 https://duepublico2.uni-due.de/receive/duepublico_mods_00077561 5051 610 5550 Administration 5550 Glucose 5550 Hyperglycemia 5550 Iatrogenic 5550 Parenteral feeding 5550 Parenteral nutrition 5550 Pediatric 5550 Treatment error