000K utf8 1100 2022$c2022-01-12 1500 eng 2050 urn:nbn:de:hbz:465-20220805-123638-6 2051 10.3390/jcm11020366 3000 Dinger, Thiemo Florin 3010 Blau, Tobias 3010 Chihi, Mehdi 3010 Darkwah Oppong, Marvin 3010 Deuschl, Cornelius 3010 Eerikäinen, Maija Susanna 3010 Gembruch, Oliver 3010 Jabbarli, Ramazan 3010 Michel, Anna 3010 Pierscianek, Daniela 3010 Sure, Ulrich 3010 Uerschels, Anne-Kathrin 3010 Wrede, Karsten Henning 4000 New Subform? Fast-Progressing, Severe Neurological Deterioration Caused by Spinal Epidural Lipomatosis [Dinger, Thiemo Florin] 4209 Spinal epidural lipomatosis (SEL) is a rare condition caused by hypertrophic growth of epidural fat. The prevalence of SEL in the Western world is approximately 1 in 40 patients and is likely to increase due to current medical and socio-economic developments. Rarely, SEL can lead to rapid severe neurological deterioration. The pathophysiology, optimal treatment, and outcome of these patients remain unclear. This study aims to widen current knowledge about this "SEL subform" and to improve its clinical management. A systematic literature review according to the PRISMA guidelines using PubMed, Scopus, Web of Science, and Cochrane Library was used to identify publications before 7 November 2021 reporting on acute/rapidly progressing, severe SEL. The final analysis comprised 12 patients with acute, severe SEL. The majority of the patients were male (9/12) and multimorbid (10/12). SEL mainly affected the thoracic part of the spinal cord (11/12), extending a median number of 7 spinal levels (range: 4-19). Surgery was the only chosen therapy (11/12), except for one critically ill patient. Regarding the outcome, half of the patients regained independence (6/11; = modified McCormick Scale ≤ II). Acute, severe SEL is a rare condition, mainly affecting multimorbid patients. The prognosis is poor in nearly 50% of the patients, even with maximum therapy. Further research is needed to stratify patients for conservative or surgical treatment. 4950 https://doi.org/10.3390/jcm11020366$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:hbz:465-20220805-123638-6$xR$3Volltext$534 4961 https://duepublico2.uni-due.de/receive/duepublico_mods_00076420 5051 610 5550 acute paraparesis 5550 atypical fat depositions 5550 neurological outcome 5550 pathophysiology 5550 spinal cord injury 5550 spinal epidural lipomatosis 5550 spinal surgery 5550 spine