@Article{duepublico_mods_00074081,
  author = 	{Mahabadi, Amir A.
		and Mahmoud, Ihab
		and Dykun, Iryna
		and Totzeck, Matthias
		and Rath, Peter-Michael
		and Ruhparwar, Arjang
		and Buer, Jan
		and Rassaf, Tienush},
  title = 	{Diagnostic value of the modified Duke criteria in suspected infective endocarditis - The PRO-ENDOCARDITIS study},
  year = 	{2021},
  month = 	{Jan},
  day = 	{27},
  keywords = 	{Infective endocarditis; Transesophageal echocardiography; Pre-test Probability; Duke criteria},
  abstract = 	{Objectives: To determine whether relevant comorbidities stratify patients with and without IE and whether these may improve the diagnostic accuracy, in addition to the modified Duke criteria. Methods and Results: 261 consecutive patients (aged 60.1 {\textpm} 16.1 years, 62.8{\%} male) with suspected IE were prospectively included in this single-center observational trial. Modified Duke criteria and relevant comorbidities as well as clinical characteristics, were assessed. Forty-seven patients had IE, as confirmed by a clinical event committee. Patients with IE had a higher frequency of positive blood cultures (70.2{\%} vs. 36.9{\%}, p < 0.0001), embolic diseases (36.2{\%} vs. 10.8{\%}, p < 0.0001), heart murmurs (27.7{\%} vs. 11.7{\%}, p = 0.01), and intensive care therapy (74.5{\%} vs. 58.4{\%}, p = 0.04). In receiver operating characteristics, the combination of modified Duke criteria without transesophageal echocardiography led to an area under the curve of 0.783 (0.715-0.851). The predictive value was only marginally improved by the addition of heart murmur and intensive care therapy (0.794 [0.724-0.863]). In contrast, transesophageal echocardiography alone achieved an area under the curve of 0.956 (0.937-0.977) and was further improved when adding modified Duke criteria, heart murmur, and intensive care therapy (0.999 [0.998-1.000]). Conclusion: Modified Duke criteria provide excellent diagnostic value for evaluating suspected IE, mainly driven by transesophageal echocardiography.},
  note = 	{The publication of this article was supported by the Publication Fund of the University of Duisburg-Essen.},
  note = 	{<p>Mahabadi, A.A., Mahmoud, I., Dykun, I., Totzeck, M., Rath, P.-M., Ruhparwar, A., Buer, J., Rassaf, T. Diagnostic value of the modified Duke criteria in suspected infective endocarditis -The PRO-ENDOCARDITIS study. <em>International Journal of Infectious Diseases</em> 104 (2021) 556--561. <a href="https://doi.org/10.1016/j.ijid.2021.01.046">https://doi.org/10.1016/j.ijid.2021.01.046</a></p>

<p>Available online 27 January 2021</p>},
  doi = 	{10.1016/j.ijid.2021.01.046},
  url = 	{https://duepublico2.uni-due.de/receive/duepublico_mods_00074081},
  url = 	{https://doi.org/10.1016/j.ijid.2021.01.046},
  file = 	{:https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00074003/Mahabadi_et_al_Diagnostic_value_modified_Duke.pdf:PDF},
  language = 	{en}
}