000K utf8 1100 2018$c2018-06-27 1500 eng 2050 urn:nbn:de:hbz:464-20210510-111432-4 2051 10.1177/0333102418783317 3000 Bottiroli, Sara 3010 Allena, Marta 3010 Avenali, Micol 3010 Bendtsen, Lars 3010 De Icco, Roberto 3010 Fadic, Ricardo 3010 Goicoechea, Maria Teresa 3010 Jensen, Rigmor Højland 3010 Katsarava, Zaza 3010 Lainez, Miguel J. A. 3010 Nappi, Giuseppe 3010 Sances, Grazia 3010 Tassorelli, Cristina 4000 Psychological, clinical, and therapeutic predictors of the outcome of detoxification in a large clinical population of medication-overuse headache$da six-month follow-up of the COMOESTAS Project [Bottiroli, Sara] 4209 Aim: To identify factors that may be predictors of the outcome of a detoxification treatment in medication-overuse headache. Methods: Consecutive patients entering a detoxification program in six centres in Europe and Latin America were evaluated and followed up for 6 months. We evaluated anxious and depressive symptomatology (though patients with severe psychiatric comorbidity were excluded), quality of life, headache-related disability, headache characteristics, and prophylaxis upon discharge. Results: Of the 492 patients who completed the six-month follow up, 407 ceased overuse following the detoxification (non overusers), another 23 ceased overuse following detoxification but relapsed during the follow-up. In the 407 non-overusers, headache acquired an episodic pattern in 287 subjects (responders). At the multivariate analyses, lower depression scores (odds ratio = 0.891; p = 0.001) predicted ceasing overuse. The primary headache diagnosis – migraine with respect to tension-type headache (odds ratio = 0.224; p = 0.001) or migraine plus tension-type headache (odds ratio = 0.467; p = 0.002) – and the preventive treatment with flunarizine (compared to no such treatment) (odds ratio = 0.891; p = 0.001) predicted being a responder. A longer duration of chronic headache (odds ratio = 1.053; p = 0.032) predicted relapse into overuse. Quality of life and disability were not associated with any of the outcomes. Conclusions: Though exploratory in nature, these findings point to specific factors that are associated with a positive outcome of medication-overuse headache management, while identifying others that may be associated with a negative outcome. Evaluation of the presence/absence of these factors may help to optimize the management of this challenging groups of chronic headache sufferers. 4950 https://doi.org/10.1177/0333102418783317$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:hbz:464-20210510-111432-4$xR$3Volltext$534 4961 https://duepublico2.uni-due.de/receive/duepublico_mods_00071851 5051 150 5051 610 5550 anxiety 5550 depression 5550 disability 5550 quality of life 5550 relapse 5550 Withdrawal