000K utf8 1100 $c2019 1500 eng 2050 urn:nbn:de:hbz:464-20191104-163328-1 2051 10.3389/fped.2019.00358 3000 Bruns, Nora 3010 Dohna-Schwake, Christian 3010 Felderhoff-Müser, Ursula 3010 Müller, Hanna 3010 Sánchez-Albisua, Iciar 3010 Tschiedel, Eva 3010 Weiß, Christel 4000 Amplitude-Integrated EEG for Neurological Assessment and Seizure Detection in a German Pediatric Intensive Care Unit. [Bruns, Nora] 4209 Objective: The aim of our study was to assess the use of aEEG in our pediatric intensive care unit (PICU), indications for neuromonitoring and its findings, utility for seizure detection, and associations with outcome. Design: We retrospectively analyzed non-neonates who were treated in our PICU and received amplitude-integrated EEG (aEEG). Patients: 27 patients aged between 29 days and 10 0/12 years (median 7.3 months) were included, who received a total of 35 aEEGS. Measurements: aEEG tracings were assessed for background (BG) pattern and its evolution, seizures, and side differences using a visual classification (Hellström-Westas). Clinical data were collected from patients' histories and analyzed for correlation with aEEG findings. Main results: While rare in early years, there was an increase in use over time. Most aEEGs were conducted because of (suspected) seizures or for management of antiepileptic treatment. aEEG had low sensitivity but high specificity for recognition of pathological BG pattern with reference to conventional EEG. Worsening of BG pattern or failure to improve was associated with death. Seizure detection rates by aEEG were higher than by clinical observation, especially for identification of non-convulsive epileptic state (ES). Side differences in aEEG were rare, but if present, they were associated with unilateral brain injury. Conclusions: aEEG is useful for the detection of seizures and ES in pediatric intensive care patients. Abnormal BG pattern and poor evolution of BG are negatively associated with survival. aEEG is a potential supplement to conventional EEG, facilitating long-term surveillance of cerebral function when continuous full-channel EEG is not available. Further investigation is needed. 4950 https://doi.org/10.3389/fped.2019.00358$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:hbz:464-20191104-163328-1$xR$3Volltext$534 4961 https://duepublico2.uni-due.de/receive/duepublico_mods_00070702 5051 610 5550 Aeeg 5550 Amplitude-integrated Eeg 5550 Continuous Eeg 5550 Neuromonitoring 5550 Outcome 5550 Pediatric Critical Care 5550 Seizure