@Article{duepublico_mods_00047088,
  author = 	{Baumann, Ralf
		and Rabaszowski, Matthaeus
		and Stenin, Igor
		and Gaertner-Akerboom, Maria
		and Scheckenbach, Kathrin
		and Wiltfang, Jens
		and Wagenmann, Martin},
  title = 	{release of IL-31 and IL-13 after nasal allergen challenge and their relation to nasal symptoms},
  year = 	{2012},
  month = 	{Aug},
  day = 	{01},
  keywords = 	{IL-13; IL-31; Kinetics; Nasal allergen; Nasal secretion},
  abstract = 	{Background: IL-31, a recently discovered member of the gp130/IL-6 cytokine family, is mainly expressed by human mast cells and T helper type 2 cells. IL-31 is a key trigger of atopic dermatitis. Recent studies also suggest a role of IL-31 in the pathogenesis of other allergic diseases including allergic rhinitis. In the present study we studied the release of IL-31 and IL-13 in allergen-challenged allergic rhinitis patients. Methods: Seven seasonal allergic volunteers underwent unilateral nasal provocation with allergen (and a control challenge) with the disc method out of the allergy season. Nasal symptom scores (rhinorrhea, itching, sneezing, obstruction) and bilateral nasal secretions were quantified before and after allergen provocation. IL-13 and IL-31 in nasal secretions and serum were measured by electrochemiluminescent immunoassay or ELISA, respectively. Results: Nasal allergen challenge induced the typical clinical symptoms and physiological changes. IL-31 and IL-13 in nasal secretions increased in four and five, respectively, volunteers at 5 h after allergen but not after control challenge. We observed correlation trends between nasal IL-31 concentrations and IL-13 concentrations (r{\thinspace}={\thinspace}0.9, p{\thinspace}={\thinspace}0.002), and IL-31 contents and symptom scores (r{\thinspace}={\thinspace}0.9, p{\thinspace}={\thinspace}0.013) 5 h after allergen provocation. No IL-31 could be detected contralaterally or systemically in the sera. Conclusions: The observed local upregulation of IL-31 mainly during the late phase reaction after nasal allergen challenge suggests a role of IL-31 in allergic rhinitis. In which way IL-31 modulates the inflammatory reaction and type 2 responses in allergic rhinitis remains to be investigated.},
  note = 	{Clinical and Translational Allergy, 2012, 2:13; Published: 1 August 2012},
  note = 	{The publication of this article was supported by the Publication Fund of the University of Duisburg-Essen.},
  doi = 	{10.1186/2045-7022-2-13},
  url = 	{https://duepublico2.uni-due.de/receive/duepublico_mods_00047088},
  url = 	{https://doi.org/10.1186/2045-7022-2-13},
  file = 	{:https://duepublico2.uni-due.de/servlets/MCRFileNodeServlet/duepublico_derivate_00046251/Baumann_et_al_Release_IL31_and_IL13.pdf:PDF},
  language = 	{en}
}