@PhdThesis{duepublico_mods_00012445,
  author = 	{Wedemeyer Dr., Christian},
  title = 	{Pr{\"a}vention und Behandlung partikelbedingter Osteolysen durch Zoledronat Zometa: Eine tierexperimentelle Studie},
  keywords = 	{Biphosphonate; Polythylenpartikelinduzierte Osteolyse; Hstomorphometrie; Osteoklasten; Endoprothesenlockerung},
  abstract = 	{The most common cause of implant failure in joint replacement is aseptic loosening due to particle-induced osteolysis. We investigated the effect of a single subcutaneous dose of  zoledronic acid (ZA) on particle-induced osteolysis. 
We utilized the murine calvaria osteolysis model in C57BL/J6 mice. Bone resorption was measured as resorption within the midline suture using Giemsa staining. Osteoclast numbers were measured per high power field using TRAP-staining. The osteoid tissue area determined. Twenty-eight mice were used, seven per group. For statistical analysis one-way ANOVA and a Student's t-test used.
Bone resorption was 0.26mm2 {\textpm} 0.09mm2 in animals with  particle implantation, 0.14mm2 {\textpm} 0.05 mm2 in animals with particle implantation and ZA treatment directly after surgery (p=0.0047), and 0.15 mm2 {\textpm} 0.05 mm2 in animals with particle implantation and ZA treatment on the fourth postoperative day (p=0.006). The osteoclast number was 8.7 {\textpm} 2.8 in animals without particle implantation and 20 {\textpm} 4 in animals with particle implantation, compared to 9.2 {\textpm} 2.5 in animals with particle implantation and ZA  treatment directly after surgery (p=0.0001), and 10.3 {\textpm} 1.4 in animals with particle implantation and ZA treatment on the fourth postoperative day (p=0.0004).
Net bone growth was significantly increased in animals with zoledronic acid treatment: 0.02 mm2 {\textpm} 0.03 mm2 in animals with particle implantation only (group 2), 0.25 mm2 {\textpm} 0.08 mm2 with particle implantation and zoledronic acid treatment directly after surgery (group 3; p=0.0018), and 0.21 mm2 {\textpm} 0.11 mm2 with particle implantation and zoledronic acid treatment on the fourth postoperative day (group 4; p=0.0042).
In summary, using the murine calvarial osteolysis model, particle-induced bone resorption was markedly decreased by a single s.c. dose of ZA and Zoledronic acid is a potent anti-resorptive drug and may also stimulate bone apposition locally in the process of particulate-induced osteolysis.},
  url = 	{https://duepublico2.uni-due.de/receive/duepublico_mods_00012445},
  file = 	{:https://duepublico2.uni-due.de/servlets/MCRZipServlet/duepublico_derivate_00013561:TYPE},
  language = 	{de}
}