000K utf8 1500 ger 2050 urn:nbn:de:hbz:464-duett-12122003-1222113 3000 4000 Bestimmung von Elementverteilungen in Krebsgeweben und Normalgeweben des humanen Gastrointestinaltraktes 4000 Determination the allocation of elements in malign and healthy tissue samples of the digestive tract 4209 In the present thesis a model is developed to calculate characteristic marks for classification of malign human tissues in the digestive tract. Different physiological and toxic elements were quantitatively determined in 68 malign tissue samples and in their corresponding healthy tissue samples from stomach, colon, and rectum by total-reflection x-ray fluorescence analysis. Microtom and high pressure digestion were used as preperation methods for the determination. A matrix was built using the element distribution, personal and pathological data to use it for t-test, principal component analysis, linear dicriminant analysis and regression. Significant higher values of phosphorus, sulphur, potassium, selenium und rubidium could be detected in the malign tissues. The calculation of grading and pT-class in comparison with the determined values results in correlation factors between 0.76 and 0.92. 4950 https://nbn-resolving.org/urn:nbn:de:hbz:464-duett-12122003-1222113$xR$3Volltext$534 4961 https://duepublico2.uni-due.de/receive/duepublico_mods_00005503 5010 54 5051 540 5550 Carcinoma 5550 chemometrics 5550 colon 5550 principal component analysis 5550 regression 5550 tissue 5550 total reflection x-ray fluorescence analysis 5550 TXRF